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Progress on major genes for high fecundity in ewes

Qiuyue LIU,Zhangyuan PAN,Xiangyu WANG,Wenping HU,Ran DI,Yaxing YAO,Mingxing CHU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 282-290 doi: 10.15302/J-FASE-2014042

Abstract: The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstratedThree major genes whose mutations can increase ovulation rate have been discovered, and all related toThe newly identified β-1,4-N-acetylgalactosaminyltransferase 2 ( ) gene of is proposed as a new mechanismis an X-linked maternally imprinted gene which increases ovulation rate.In addition, several putative major genes need to be verified.

Keywords： major gene     ovulation rate     sheep     reproduction    

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The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 343-348 doi: 10.15302/J-FEM-2016053

Abstract: This paper discusses the two major root causes of smog in China.The second major cause of smog is the low quality diesel and outdated diesel engines used in China.

Keywords： smog     emissions     coal refining     coal utilization     solutions    

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Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 528-540 doi: 10.1007/s11684-020-0798-1

Abstract: Major depressive disorder (MDD) causes great decrements in health and quality of life with increments

Keywords： psychoradiology     major depressive disorder     MRI     biomarker    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Arbuscular mycorrhizal associations and the major regulators

Li XUE, Ertao WANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 296-306 doi: 10.15302/J-FASE-2020347

Abstract:

Plants growing in natural soils encounter diverse biotic and abiotic stresses and have adapted with sophisticated strategies to deal with complex environments such as changing root system structure, evoking biochemical responses and recruiting microbial partners. Under selection pressure, plants and their associated microorganisms assemble into a functional entity known as a holobiont. The commonest cooperative interaction is between plant roots and arbuscular mycorrhizal (AM) fungi. About 80% of terrestrial plants can form AM symbiosis with the ancient phylum Glomeromycota. A very large network of extraradical and intraradical mycelium of AM fungi connects the underground biota and the nearby carbon and nutrient fluxes. Here, we discuss recent progress on the regulators of AM associations with plants, AM fungi and their surrounding environments, and explore further mechanistic insights.

Keywords： AM symbiosis     signal     regulators     nutrients     phosphate     microbiota    

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Life cycle and performance based seismic design of major bridges in China

FAN Lichu

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 3,   Pages 261-266 doi: 10.1007/s11709-007-0033-z

Abstract: The idea of life cycle and performance based seismic design of major bridges is introduced.components, different seismic design levels and expected performance objectives are suggested for the majorassessment, are also proposed to be the important issues to study in order to guide the seismic design of major

Keywords： controllability     progressive     reparability     different     important    

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Value Management Practices on Major Construction Projects and Green Building

Ru-jiang Zhao,Wung Hee Moh

Frontiers of Engineering Management 2016, Volume 3, Issue 2,   Pages 147-157 doi: 10.15302/J-FEM-2016018

Abstract: The paper starts with background information on value management (VM) in the construction industry and current development situation of the green building industry, and costs and profitability of green buildings. The paper continues with detailed analyses of the findings, covering new developments and perceptions of VM, and applications of VM in the industry. The paper also reports case studies on the practices adopted in the planning and design management phase of SIPO Guangdong Patent Examination Cooperation Center and in the construction management phase of Guangzhou International Bio-Island Standard Property Unit II project. As revealed by the practices, the value-adds and savings in construction costs through the application of VM are important for the developers, and the contributions of VM application in green building projects are significant to achieving the expected targets and to resolving the design and construction challenges encountered in the development of green building industry. And the paper presents, findings on how VM can improve construction management and coordination of several ongoing construction projects and on how VM can be systematically implemented by phases, and discussions on other potential benefits of using VM systems.

Keywords： value management (VM)     VM theory and practices     Chinese construction industry     green buildings    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 487-495 doi: 10.1007/s11684-015-0413-z

Abstract: This study aimed to investigate the temporal trend of eight major cancers in Xuanwei County using datastudies are warranted to systematically examine the underlying reasons for the temporal trend of the major

Keywords： cancer     mortality     Xuanwei     temporal trend    

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Environmental and human health impact assessment of major interior wall decorative materials

Bingqing ZHANG, Ruochen ZENG, Xiaodong LI

Frontiers of Engineering Management 2019, Volume 6, Issue 3,   Pages 406-415 doi: 10.1007/s42524-019-0025-4

Abstract: Despite the growing interest in green products in the interior wall decorative material market, knowledge gaps exist because determining which product is more environmental and user friendly than the others is difficult. This work assesses the environmental and human health profiles of interior latex and wallpaper. Two interior latex products of different raw material ratios and one non-woven wallpaper product are considered. The environmental impact assessment follows life cycle assessment (LCA) methodology and applies Building Environmental Performance Analysis System (BEPAS). The human health impact is based on impact-pathway chain and is performed using Building Health Impact Analysis System (BHIAS). The assessment scope, associated emissions, and territorial scope of various emissions are defined to facilitate comparison study of interior wall decorative products. The impacts are classified into 15 categories belonging to three safeguard areas: ecological environment, natural resources, and human health. The impacts of categories are calculated and monetized using willingness to pay (WTP) and disability-adjusted life year (DALY) and summarized as an integrated external cost of environmental and human health impacts. Assessment results reveal that the integrated impact of interior latex is lower than that of non-woven wallpaper, and the interior latex of low quality causes low life cycle integrated impact. The most impacted categories are global warming, respiratory effects, and water consumption. Hotspots of product manufacturing are recognized to promote green product design.

Keywords： life cycle assessment     human health impact     integrated assessment     interior wall decorative material     green product    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: rapid development of biotechnology has provided a greater understanding of the biological functions of majorfunctions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Review on Major Planning Projects & Frontier Issues about Global Engineering Science and Technology inMajor Countries

Song Chao,Sun Shengkai,Chen Jindong,Wang Yaqiong,Kan Xiaowei,Wei Chang and Cui Jian

Strategic Study of CAE 2017, Volume 19, Issue 1,   Pages 4-12 doi: 10.15302/J-SSCAE-2017.01.002

Abstract:

This paper examines recent major strategic planning projects in engineeringscience and technology from several major countries around the world, and briefly analyzes the currentdevelopment status of major fields.

Keywords： engineering science and technology     major countries     major planning projects     frontier issue     focus    

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Implementation of a flexible Major Vacation Toll-free Program for small passenger vehicles in China

Meng XU, Ziyou GAO

Frontiers of Engineering Management 2017, Volume 4, Issue 4,   Pages 498-499 doi: 10.15302/J-FEM-2017111

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Title Author Date Type Operation

Progress on major genes for high fecundity in ewes

Qiuyue LIU,Zhangyuan PAN,Xiangyu WANG,Wenping HU,Ran DI,Yaxing YAO,Mingxing CHU

Journal Article

The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Journal Article

Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Arbuscular mycorrhizal associations and the major regulators

Li XUE, Ertao WANG

Journal Article

Life cycle and performance based seismic design of major bridges in China

FAN Lichu

Journal Article

Value Management Practices on Major Construction Projects and Green Building

Ru-jiang Zhao,Wung Hee Moh

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Journal Article

Environmental and human health impact assessment of major interior wall decorative materials

Bingqing ZHANG, Ruochen ZENG, Xiaodong LI

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Review on Major Planning Projects & Frontier Issues about Global Engineering Science and Technology inMajor Countries

Song Chao,Sun Shengkai,Chen Jindong,Wang Yaqiong,Kan Xiaowei,Wei Chang and Cui Jian

Journal Article

Implementation of a flexible Major Vacation Toll-free Program for small passenger vehicles in China

Meng XU, Ziyou GAO

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article